Christian Hesslinger Selected Research

2- (2- (4- methoxypyridin- 2- yl)ethyl)- 3H- imidazo(4,5- b)pyridine

4/2006

In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.

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Christian Hesslinger Research Topics

Disease

8	Idiopathic Pulmonary Fibrosis 01/2023 - 10/2019
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 08/2009
2	Inflammation (Inflammations) 08/2009 - 04/2006
1	Disease Progression 01/2024
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2023
1	Cicatrix (Scar) 12/2022
1	Rare Diseases (Rare Disease) 12/2022
1	Psoriatic Arthritis 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022
1	Vomiting 01/2022
1	Pneumonia (Pneumonitis) 08/2009
1	Lung Diseases (Lung Disease) 08/2009
1	Respiratory Tract Diseases (Respiratory Tract Disease) 08/2009
1	Hypotension (Low Blood Pressure) 04/2006
1	Hypoxia (Hypoxemia) 10/2004
1	Phenylketonurias (Phenylketonuria) 09/2003
1	Hypertension (High Blood Pressure) 09/2003
1	Parkinson Disease (Parkinson's Disease) 04/2003

Drug/Important Bio-Agent (IBA)

4	BI 1015550IBA 01/2023 - 01/2022
2	Biomarkers (Surrogate Marker)IBA 01/2024 - 10/2019
2	Proteins (Proteins, Gene)FDA Link 02/2022 - 01/2022
2	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 01/2022
2	Dopamine (Intropin)FDA LinkGeneric 10/2004 - 04/2003
2	sapropterin (tetrahydrobiopterin)FDA Link 09/2003 - 04/2003
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2023
1	nintedanibIBA 12/2022
1	pirfenidoneIBA 12/2022
1	Oxygen (Dioxygen)IBA 12/2022
1	RoflumilastIBA 01/2022
1	apremilastIBA 01/2022
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2022
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2022
1	Phosphodiesterase 4 InhibitorsIBA 01/2022
1	Metalloproteases (Metalloproteinases)IBA 03/2020
1	Matrix Metalloproteinases (MMPs)IBA 03/2020
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2009
1	Lysine (L-Lysine)FDA Link 08/2009
1	GW 274150IBA 08/2009
1	IsoenzymesIBA 08/2009
1	N(6)-(1-iminoethyl)lysineIBA 08/2009
1	SmokeIBA 08/2009
1	2- (2- (4- methoxypyridin- 2- yl)ethyl)- 3H- imidazo(4,5- b)pyridineIBA 04/2006
1	LipopolysaccharidesIBA 04/2006
1	benzocycloheptapyridineIBA 04/2006
1	Histamine (Histamine Dihydrochloride)FDA Link 10/2004
1	GuanosineIBA 09/2003
1	MineralocorticoidsIBA 09/2003
1	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 09/2003
1	EnzymesIBA 09/2003
1	ReninIBA 09/2003
1	SaltsIBA 09/2003
1	Superoxides (Superoxide)IBA 09/2003
1	Desoxycorticosterone Acetate (DOCA)FDA Link 09/2003
1	Desoxycorticosterone (Deoxycorticosterone)IBA 09/2003
1	NADPH Oxidases (NAD(P)H oxidase)IBA 09/2003
1	Endothelin-1 (Endothelin 1)IBA 09/2003
1	Acetates (Acetic Acid Esters)FDA Link 09/2003
1	AntioxidantsIBA 04/2003
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2003
1	Glutathione (Reduced Glutathione)IBA 04/2003
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 04/2003